Author: Rashmi Mohanty; Xinquan Liu; Jae You Kim; Xiujuan Peng; Sahil Bhandari; Jasmim Leal; Dhivya Arasappan; Dennis C. Wylie; Tony Dong; Debadyuti Ghosh
Title: Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment Document date: 2019_6_4
ID: e2uzk4u1_62
Snippet: Taking advantage of the molecular diversity of peptide-presenting phage libraries and their physicochemical properties, we are able to screen, iterate, and select peptides that can overcome the selection barrier of the tumor ECM to achieve permeating transport. The use of next-generation DNA sequencing allows us to expand the sequence sample space of peptides that can be analyzed and tested for improved transport. From next-generation sequencing .....
Document: Taking advantage of the molecular diversity of peptide-presenting phage libraries and their physicochemical properties, we are able to screen, iterate, and select peptides that can overcome the selection barrier of the tumor ECM to achieve permeating transport. The use of next-generation DNA sequencing allows us to expand the sequence sample space of peptides that can be analyzed and tested for improved transport. From next-generation sequencing data and in silico analysis, we identified specific peptides and motif sequences that enhanced transport through the ECM barrier.
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