Author: Jun Wu; Dingyun Song; Zhongwen Li; Baojie Guo; Yani Xiao; Wenjing Liu; Lingmin Liang; Chunjing Feng; Tingting Gao; Zai Wang; Jianyan Wen; Shengnan Yang; Peipei Liu; Lei Wang; Yukai Wang; Liang Peng; Guihai Feng; Shiqiang Huang; Glyn Nigel Stacey; Wei Li; Yan Huo; Ronghua Jin; Qi Zhou; Liu Wang; Baoyang Hu; Huaping Dai; Jie Hao
Title: Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis Document date: 2020_4_16
ID: 8dpla6jt_50
Snippet: This is important because IDO1 (indoleamine 2, 3-dioxygenase 1) has been shown to mediate 414 immunosuppression in T cell-inflamed microenvironments through its catabolism of tryptophan and thus 415 suppression of the tryptophan-kynurenine-aryl hydrocarbon receptor (Trp-Kyn-AhR) pathway in T 416 cells. To further characterize IMRCs at a molecular level, we conducted genome-wide RNA profiling to 417 compare IMRCs with UCMSCs, after IFN-γ stimulat.....
Document: This is important because IDO1 (indoleamine 2, 3-dioxygenase 1) has been shown to mediate 414 immunosuppression in T cell-inflamed microenvironments through its catabolism of tryptophan and thus 415 suppression of the tryptophan-kynurenine-aryl hydrocarbon receptor (Trp-Kyn-AhR) pathway in T 416 cells. To further characterize IMRCs at a molecular level, we conducted genome-wide RNA profiling to 417 compare IMRCs with UCMSCs, after IFN-γ stimulation (Fig. 3C) . Hierarchical clustering revealed that 418
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