Author: Luis M. Colon-Perez; Kristen R. Ibanez; Mallory Suarez; Kristin Torroella; Kelly Acuna; Edward Ofori; Yona Levites; David E. Vaillancourt; Todd E. Golde; Paramita Chakrabarty; Marcelo Febo
Title: Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6 Document date: 2019_2_27
ID: hyeygk64_4
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/562348 doi: bioRxiv preprint considered ideal for testing the individual or combined effects of Aβ and neuroinflammation on in vivo tissue microstructure in mouse brain. Collectively, free water and NODDI processing in Aβexpressing TgCRND8 mice revealed a microstructure pattern consistent with a reduced volume of the extracellula.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/562348 doi: bioRxiv preprint considered ideal for testing the individual or combined effects of Aβ and neuroinflammation on in vivo tissue microstructure in mouse brain. Collectively, free water and NODDI processing in Aβexpressing TgCRND8 mice revealed a microstructure pattern consistent with a reduced volume of the extracellular space along with an increase in geometrically misoriented (dispersed) axons or dendritic processes. Interestingly, we discovered a novel relationship between NODDI metrics modeling the density and orientation dispersion of neurites and a measure of functional network clustering that was similarly affected by Aβ and IL6.
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