Selected article for: "carriage density and monocyte recruitment"
Author: Simon P. Jochems; Fernando Marcon; Beatriz F. Carniel; Mark Holloway; Elena Mitsi; Emma Smith; Jenna F. Gritzfeld; Carla Solórzano; Jesús Reiné; Sherin Pojar; Elissavet Nikolaou; Esther L. German; Angie Hyder-Wright; Helen Hill; Caz Hales; Wouter A.A de Steenhuijsen Piters; Debby Bogaert; Hugh Adler; Seher Zaidi; Victoria Connor; Jamie Rylance; Helder I. Nakaya; Daniela M. Ferreira
Title: Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage
  • Document date: 2018_6_20
    • ID: 4fgz09cv_17
    Snippet: Relative cytokine production highly correlated (r = 0.66, p < 0.0001) between the two cell 167 populations, suggesting that nasal monocytes/macrophages could be the source of these 168 cytokines. This is supported by the observation that in carriers with low carriage density (only 169 detectable by molecular methods), absence of monocyte recruitment associated with absent Spn- Table S4 ). Carriage without LAIV induced 834 and 176 differentially 8.....
    Document: Relative cytokine production highly correlated (r = 0.66, p < 0.0001) between the two cell 167 populations, suggesting that nasal monocytes/macrophages could be the source of these 168 cytokines. This is supported by the observation that in carriers with low carriage density (only 169 detectable by molecular methods), absence of monocyte recruitment associated with absent Spn- Table S4 ). Carriage without LAIV induced 834 and 176 differentially 8 expressed genes (DEG) at day 2 and day 9, respectively (Fig 5a) . These genes were enriched for 176 pathways associated with Gap junction trafficking and regulation (including GJA1, TJP1 and 177 multiple GJB) and degradation of the extracellular matrix (including COL17A1, COL12A1, LAMA3, 178 KLK7). In the carriage-group, a smaller number of DEG was observed (161 and 248 at day 2 and 179 day 9, respectively).

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