Author: Shuai Xia; Meiqin Liu; Chao Wang; Wei Xu; Qiaoshuai Lan; Siliang Feng; Feifei Qi; Linlin Bao; Lanying Du; Shuwen Liu; Chuan Qin; Fei Sun; Zhengli Shi; Yun Zhu; Shibo Jiang; Lu Lu
Title: Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion Document date: 2020_3_12
ID: j5bepvvw_28
Snippet: In the other two regions, E918 binds to R1166 and K929 binds to E1163 in 393 SARS-CoV, both of which were enhanced in SARS-CoV-2. These results suggest that 394 this new HCoV has evolved with improved binding affinity between HR1 and HR2 395 domains, which may accelerate the viral membrane fusion process and enhance viral 396 infectivity or transmissibility. A recent study also found that the binding affinity 397 between ACE2 receptor on the host.....
Document: In the other two regions, E918 binds to R1166 and K929 binds to E1163 in 393 SARS-CoV, both of which were enhanced in SARS-CoV-2. These results suggest that 394 this new HCoV has evolved with improved binding affinity between HR1 and HR2 395 domains, which may accelerate the viral membrane fusion process and enhance viral 396 infectivity or transmissibility. A recent study also found that the binding affinity 397 between ACE2 receptor on the host cell and RBD in S protein of SARS-CoV-2 is 398 more than 10-fold higher than that of SARS-CoV, which may also be associated with 399 the increased infectivity and transmissibility of SARS-CoV-2 12 .
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