Selected article for: "expression level and low expression level"
Author: Michael T. Parker; Smita Gopinath; Corey E. Perez; Melissa M. Linehan; Jason M. Crawford; Akiko Iwasaki; Brett D. Lindenbach
Title: Innate Immune Priming by cGAS as a Preparatory Countermeasure Against RNA Virus Infection
  • Document date: 2018_10_3
    • ID: j1gkl43g_17
    Snippet: While ISG expression served as a convenient and sensitive readout of baseline 375 cGAS-STING activation in our studies, it should be noted that we did not 376 demonstrate that low-level ISG expression directly contributes to RNA virus 377 restriction. On the surface, our results may seem at odds with those of Franz et al., 378 who recently reported that STING restricts RNA viruses, including VSV, in an 379 ISG-independent manner (20). However, we.....
    Document: While ISG expression served as a convenient and sensitive readout of baseline 375 cGAS-STING activation in our studies, it should be noted that we did not 376 demonstrate that low-level ISG expression directly contributes to RNA virus 377 restriction. On the surface, our results may seem at odds with those of Franz et al., 378 who recently reported that STING restricts RNA viruses, including VSV, in an 379 ISG-independent manner (20). However, we do not exclude the possibility that 380 smoldering cGAS activation may also contribute to ISG-independent mechanisms of 381 virus restriction via STING. 382

    Search related documents:
    Co phrase search for related documents
    • cgas activation and low level: 1, 2
    • cgas activation and low level ISG expression: 1
    • cgas activation and RNA virus: 1, 2, 3, 4, 5, 6, 7
    • cgas activation and smoldering cgas activation: 1
    • cgas activation and virus restriction: 1, 2, 3, 4
    • ISG expression and low level: 1
    • ISG expression and low level ISG expression: 1
    • ISG expression and RNA virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • ISG expression and virus restriction: 1, 2, 3
    • low level and RNA virus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • low level and smoldering cgas activation: 1
    • low level and virus restriction: 1, 2, 3, 4
    • low level ISG expression and RNA virus: 1
    • low level ISG expression and virus restriction: 1
    • RNA virus and smoldering cgas activation: 1
    • RNA virus and virus restriction: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • smoldering cgas activation and virus restriction: 1