Selected article for: "airway cell and illness severity"
Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection
  • Document date: 2019_5_20
    • ID: bx49tbui_58
    Snippet: We sought to understand target organ resident cell responses during primary RSV infection in the first year of life in infants displaying the full spectrum of illness severity. We implemented our recently described nasal cell sampling procedure 35, 47 to measure infant airway transcriptional responses. Of the 139 RSV infected infants enrolled in the AsPIRES study, 106 had satisfactory nasal samples and gene expression results for analysis. Demogr.....
    Document: We sought to understand target organ resident cell responses during primary RSV infection in the first year of life in infants displaying the full spectrum of illness severity. We implemented our recently described nasal cell sampling procedure 35, 47 to measure infant airway transcriptional responses. Of the 139 RSV infected infants enrolled in the AsPIRES study, 106 had satisfactory nasal samples and gene expression results for analysis. Demographic data of these 106 infants are described in Table 1 . Infants ranged from 0.5 to 9.4 months of age (mean age 3.3 months) and were equally distributed by gender. Sixty-three (59%) were hospitalized during the infection while the other 43 were managed as outpatients.

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