Selected article for: "pathway signal and signal pathway"
Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection
  • Document date: 2019_5_20
    • ID: bx49tbui_76
    Snippet: Interestingly, pathway analysis (Fig. 3A) indicated there was a strong signal of increasing EIF2 and mTOR signaling, and alterations in mitochondrial and oxidative phosphorylation activity, over time. Less surprisingly, there was also an indication of diminishing innate interferon signaling over time. The genes contributing to this signature included multiple intracellular IFN signaling molecules (MX1, IFIT1, STAT2), but not the ligands or recept.....
    Document: Interestingly, pathway analysis (Fig. 3A) indicated there was a strong signal of increasing EIF2 and mTOR signaling, and alterations in mitochondrial and oxidative phosphorylation activity, over time. Less surprisingly, there was also an indication of diminishing innate interferon signaling over time. The genes contributing to this signature included multiple intracellular IFN signaling molecules (MX1, IFIT1, STAT2), but not the ligands or receptors themselves. We performed exploratory analysis of these IFN pathway-related genes to better understand their expression patterns in our subjects.

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