Insufficiency in airway interferon activation defines clinical severity to infant RSV infection

Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani

When identifying gene expression correlates of severity in this population, we were not surprised to identify many chemokines that are reflective of a more robust inflammatory response (Fig. 1) . Somewhat more insightful is the ontological analysis that implicates robust changes in IL17 signaling in severe patients, when compared to those with milder forms of illness, specifically in the airway. Likewise, the data implicate airway changes in IL-1, -8, and 10 signaling, and alterations in matrix metalloproteinase activity. Of additional novel insight, our data suggests the nature of the inflammatory response in the airway differs in infants with severe RSV-associated illness. In particular, our data All rights reserved. No reuse allowed without permission.