Author: Xiang He; Lei Zhang; Qin Ran; Anying Xiong; Junyi Wang; Dehong Wu; Feng Chen; Guoping Li
Title: Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV Document date: 2020_2_5
ID: mjhez5im_18
Snippet: The copyright holder for this preprint . https://doi.org/10.1101/2020.02.03.20020206 doi: medRxiv preprint production of acute respiratory distress syndrome-associated cytokines (7) . ACE2 is also related to adaptive immune responses (8) . In this current study, the GSEA analysis showed that the high expression of ACE2 was related to innate immune response, acquired immune response, B cell regulatory immunity and cytokine secretion, and enhanced .....
Document: The copyright holder for this preprint . https://doi.org/10.1101/2020.02.03.20020206 doi: medRxiv preprint production of acute respiratory distress syndrome-associated cytokines (7) . ACE2 is also related to adaptive immune responses (8) . In this current study, the GSEA analysis showed that the high expression of ACE2 was related to innate immune response, acquired immune response, B cell regulatory immunity and cytokine secretion, and enhanced the inflammatory response induced by IL-1, IL-10, IL-6, IL-8 cytokines. We speculated that the immune system dysfunction involved in the high expression of . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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