Selected article for: "cytokine release and necrosis factor"
Author: David E. Ochayon; Ayad Ali; Pablo C. Alarcon; Durga Krishnamurthy; Leah C. Kottyan; Michael Borchers; Stephen N. Waggoner
Title: Interleukin-33 promotes type 1 cytokine expression via p38 MAPK in human natural killer cells
  • Document date: 2019_9_20
    • ID: iuhhuy53_1
    Snippet: Natural killer (NK) cells play a key role in the clearance of virus-infected cells and the pathogenesis of many diseases [1] [2] [3] . The type 1 cytokine interleukin-12 (IL-12) provokes a canonical interferon-gamma (IFN-) response by NK cells 4 . Other type 1 cytokines, including IL-15, IL-18 and IL-1 enhance IL-12-induced IFN- release by NK cells [5] [6] [7] [8] [9] [10] . This type 1 cytokine synergy can also promote enhanced release .....
    Document: Natural killer (NK) cells play a key role in the clearance of virus-infected cells and the pathogenesis of many diseases [1] [2] [3] . The type 1 cytokine interleukin-12 (IL-12) provokes a canonical interferon-gamma (IFN-) response by NK cells 4 . Other type 1 cytokines, including IL-15, IL-18 and IL-1 enhance IL-12-induced IFN- release by NK cells [5] [6] [7] [8] [9] [10] . This type 1 cytokine synergy can also promote enhanced release of tumor necrosis factor-alpha (TNF) and granulocyte macrophage colony stimulating factor (GM-CSF). Thus, type 1 cytokine rich environments associated with immune insults such as infection or injury can stimulate cytokine responses from NK cells that further promote type 1 responses. For example, in the experimental model of Leishmania infantum, the combination of IL-12 and IL-18 is critical for NK-cell IFN- expression 11 .

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