Author: David E. Ochayon; Ayad Ali; Pablo C. Alarcon; Durga Krishnamurthy; Leah C. Kottyan; Michael Borchers; Stephen N. Waggoner
Title: Interleukin-33 promotes type 1 cytokine expression via p38 MAPK in human natural killer cells Document date: 2019_9_20
ID: iuhhuy53_2
Snippet: A central dogma of cytokine biology holds that type 1 cytokines (e.g. IL-12) suppress type 2 cytokine responses, while type 2 cytokines (e.g. IL-4) correspondingly suppress type 1 responses 12, 13 . Thus, type 2 cytokines should putatively suppress NK-cell production of IFN-ï§. Yet the prototypical typical type 2 cytokine IL-4, alone or in combination with IL-12, triggered high levels of IFN-ï§ expression by mouse NK cells 14, 15 . Another type.....
Document: A central dogma of cytokine biology holds that type 1 cytokines (e.g. IL-12) suppress type 2 cytokine responses, while type 2 cytokines (e.g. IL-4) correspondingly suppress type 1 responses 12, 13 . Thus, type 2 cytokines should putatively suppress NK-cell production of IFN-ï§. Yet the prototypical typical type 2 cytokine IL-4, alone or in combination with IL-12, triggered high levels of IFN-ï§ expression by mouse NK cells 14, 15 . Another type 2 cytokine, IL-33, can enhance IL-12-induced production of IFN-ï§ by both NK and NKT cells [16] [17] [18] . Thus, NK cells in type 2 cytokine rich environments may exhibit hypersensitive IFN-ï§ responses following IL-12-inducing infections or insults.
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