Selected article for: "activity inhibition and broad spectrum"
Author: Aleksandra Milewska; Katherine Falkowski; Magdalena Kalinska; Ewa Bielecka; Antonina Naskalska; Pawel Mak; Adam Lesner; Marek Ochman; Maciej Urlik; Jan Potempa; Tomasz Kantyka; Krzysztof Pyrc
Title: Kallikrein 13: a new player in coronaviral infections
  • Document date: 2020_3_2
    • ID: 6om1y33o_7
    Snippet: Receptor recognition is the first, essential step of the virus infection process. The The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.01.971499 doi: bioRxiv preprint concentrations(63). Broad spectrum protease inhibitors are now used widely for virus research, 281 although their non-specific activity makes the results equivocal. For example, Matsuyama et al. 282 showed recently that th.....
    Document: Receptor recognition is the first, essential step of the virus infection process. The The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.01.971499 doi: bioRxiv preprint concentrations(63). Broad spectrum protease inhibitors are now used widely for virus research, 281 although their non-specific activity makes the results equivocal. For example, Matsuyama et al. 282 showed recently that the furin inhibitor dec-RVKR-CMK interferes with the activity of several 283 proteases, and that its previously described inhibitory activity during MERS-CoV infection is 284 not specific to furin; instead, its activity is due to non-specific inhibition of cathepsin L and 285 TMPRSS2 (81). We tried to use specific KLK inhibitors developed in our laboratory (61).

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