Large-scale analysis of redox-sensitive conditionally disordered protein regions reveal their widespread nature and key roles in high-level eukaryotic processes

Gábor Erdos; Bálint Mészáros; Dana Reichmann; Zsuzsanna Dosztányi

Full proteomes were downloaded from the 23/08/2018 version of UniProt reference proteomes [24] . The customized IUPred2A was run on all protein sequences from all proteins, using the redox-sensitive option. A protein was considered to contain a redox-sensitive conditionally disordered region if IUPred2A returned at least one region. The fredox value of a proteome was calculated as the number of proteins with predicted regions over the total number of regions in the proteome. In total, the analyzed data consisted of 192 viral, 436 archaeal, 608 bacterial, and 167 eukaryotic proteomes. The proteomes, together with the number of predicted redoxsensitive conditionally disordered proteins and fredox, are listed in the Supplementary material.