Author: Cheng Wang; Shaobo Wang; Daixi Li; Xia Zhao; Songling Han; Tao Wang; Gaomei Zhao; Yin Chen; Fang Chen; Jianqi Zhao; Liting Wang; Wei Sun; Yi Huang; Yongping Su; Dongqing Wei; Jinghong Zhao; Junping Wang
Title: Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2 Document date: 2020_3_31
ID: bzq1xxqb_17
Snippet: Nevertheless, HD5 had less of an effect on ACE2-S1 interaction ( Figure 2B) , possibly due to a binding site distant from the RBD. Recent studies have discovered some antibodies and peptides with high affinities binding to the spike 32, 35 . These candidates are placed hopes on suppressing 2019-nCoV. Of note, our findings imply that the binding affinity alone is insufficient to predict the therapeutic potential of drugs......
Document: Nevertheless, HD5 had less of an effect on ACE2-S1 interaction ( Figure 2B) , possibly due to a binding site distant from the RBD. Recent studies have discovered some antibodies and peptides with high affinities binding to the spike 32, 35 . These candidates are placed hopes on suppressing 2019-nCoV. Of note, our findings imply that the binding affinity alone is insufficient to predict the therapeutic potential of drugs.
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