Author: Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings
Title: Life course exposures continually shape antibody profile and risk of seroconversion to influenza Document date: 2020_1_16
ID: cyxn7dpw_57
Snippet: Individual antibody profiles were constructed using each individual's HAI titers against 21 tested H3N2 strains which were sorted in chronological order. We characterized the shape of these individual antibody profiles using a number of statistics (Fig. 3) which are proposed to approximately estimate the area under the antigenic landscape surface (Area Under the Curve, AUC), the breadth of antibody profile (Width, W), where the breadth is calcula.....
Document: Individual antibody profiles were constructed using each individual's HAI titers against 21 tested H3N2 strains which were sorted in chronological order. We characterized the shape of these individual antibody profiles using a number of statistics (Fig. 3) which are proposed to approximately estimate the area under the antigenic landscape surface (Area Under the Curve, AUC), the breadth of antibody profile (Width, W), where the breadth is calculated above either detective (1:10) or protective threshold (1:40), and the temporal targeting of antibody profile by the measured HAI titer values (Averaged Titer Year, ATY). The statistics are calculated as follows:
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