Author: Kenneth Lyon; Luis U. Aguilera; Tatsuya Morisaki; Brian Munsky; Timothy J. Stasevich
Title: Live-cell single RNA imaging reveals bursts of translational frameshifting Document date: 2018_11_24
ID: 4fm1skgh_174
Snippet: Parameter estimation. For each model, we sought to find a single parameter set that reproduces all experimental data. Given the different sources of experimental data we estimated the parameter values using a multi-objective optimization strategy to simultaneously compare the Harringtonine run-off data, the fractions of shifted and nonshifted spots and the ribosome occupancy, as follows:.....
Document: Parameter estimation. For each model, we sought to find a single parameter set that reproduces all experimental data. Given the different sources of experimental data we estimated the parameter values using a multi-objective optimization strategy to simultaneously compare the Harringtonine run-off data, the fractions of shifted and nonshifted spots and the ribosome occupancy, as follows:
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