Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection Document date: 2019_12_23
ID: ahs2wdus_7
Snippet: In addition to restriction of IAV, IFITM3 has been shown to restrict an 127 additional sixteen mostly enveloped RNA viruses including human 128 immunodeficiency virus 1 (HIV-1), Ebola and Dengue virus (1, 7-10). The 129 tropism of these IFITM3-restricted viruses is highly varied; IAV predominantly 130 epithelial cells of the respiratory system (11), HIV-1 predominantly infects 131 CD4 + T cells (12, 13) and Dengue virus can infect skin epithelial.....
Document: In addition to restriction of IAV, IFITM3 has been shown to restrict an 127 additional sixteen mostly enveloped RNA viruses including human 128 immunodeficiency virus 1 (HIV-1), Ebola and Dengue virus (1, 7-10). The 129 tropism of these IFITM3-restricted viruses is highly varied; IAV predominantly 130 epithelial cells of the respiratory system (11), HIV-1 predominantly infects 131 CD4 + T cells (12, 13) and Dengue virus can infect skin epithelial and 132
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