Author: Deepak Kumar; Nitin Sharma; Murali Aarthy; Sanjeev Singh; Rajanish Giri
Title: Mechanistic insights into Zika virus NS3 helicase inhibition by Epigallocatechin-3-gallate: Supplementary Files Document date: 2019_1_26
ID: k11iupe0_17
Snippet: NTPase activity inhibition by EGCG has already been reported in literature against bacterial DNA gyrases(33). Our molecular docking and simulation studies have shown that EGCG can bind to both the active sites (NTPase and RNA binding site) of ZIKV NS3 helicase with significant interactions between critical residues. Since NTP hydrolysis provides the required energy to open up RNA secondary structures during replication, we firstly focused on the .....
Document: NTPase activity inhibition by EGCG has already been reported in literature against bacterial DNA gyrases(33). Our molecular docking and simulation studies have shown that EGCG can bind to both the active sites (NTPase and RNA binding site) of ZIKV NS3 helicase with significant interactions between critical residues. Since NTP hydrolysis provides the required energy to open up RNA secondary structures during replication, we firstly focused on the NTPase activity inhibition assays experimentally.
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