Author: Václav Vopálenský; Michal Sýkora; Tomáš Mašek; Martin Pospíšek
Title: Messenger RNAs transcribed from yeast linear cytoplasmic plasmids possess unconventional 5’ and 3’ UTRs and suggest a novel mechanism of translation Document date: 2018_5_17
ID: foskvkwn_3
Snippet: The smaller plasmid, pGKL1, contains four open reading frames (ORFs): two of them (K1ORF2 and K1ORF4) encode precursors of killer toxin subunits (8-10); K1ORF3 is involved in an immunity phenotype in an unknown manner (11), and K1ORF1 codes for the pGKL1 plasmid-specific DNA polymerase and a terminal protein (12,13). Eleven ORFs have been reported in the larger pGKL2 plasmid, which provides vital functions for pGKL1/pGKL2 maintenance in host cell.....
Document: The smaller plasmid, pGKL1, contains four open reading frames (ORFs): two of them (K1ORF2 and K1ORF4) encode precursors of killer toxin subunits (8-10); K1ORF3 is involved in an immunity phenotype in an unknown manner (11), and K1ORF1 codes for the pGKL1 plasmid-specific DNA polymerase and a terminal protein (12,13). Eleven ORFs have been reported in the larger pGKL2 plasmid, which provides vital functions for pGKL1/pGKL2 maintenance in host cell (14) . Some functions have been attributed to more than half of the proteins encoded by the ORFs carried by the pGKL2 plasmid. K2ORF2 codes for a pGKL2-specific DNA polymerase and a terminal protein (5,15). K2ORF3 codes for a virus-like mRNA capping enzyme. A purified K2Orf3 protein (K2Orf3p) displayed 5'triphosphatase (TPase) and RNA-guanylyltransferase (GTase) activities; however the predicted RNA cap (guanine-N 7 )-methyltransferase (MTase) activity, which is the third crucial activity of conventional mRNA capping complexes, was not detected (16,17).
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