Author: Václav Vopálenský; Michal Sýkora; Tomáš Mašek; Martin Pospíšek
Title: Messenger RNAs transcribed from yeast linear cytoplasmic plasmids possess unconventional 5’ and 3’ UTRs and suggest a novel mechanism of translation Document date: 2018_5_17
ID: foskvkwn_46
Snippet: More than half of all pGKL ORFs (9) contained 5' untranslated regions (UTRs) composed exclusively of adenosine nucleotides (Figs. 3C; Tables S1A,S5 ) regardless of their template or non-template origin, thus resembling adenosine-rich yeast internal ribosome entry sites (IRESs) (38). The transcripts arising from pGKL1 promoters tended to have longer and more uncapped 5' poly(A) leaders than pGKL2 transcripts ( Fig. 3C ; Table S1A ). Additionally, .....
Document: More than half of all pGKL ORFs (9) contained 5' untranslated regions (UTRs) composed exclusively of adenosine nucleotides (Figs. 3C; Tables S1A,S5 ) regardless of their template or non-template origin, thus resembling adenosine-rich yeast internal ribosome entry sites (IRESs) (38). The transcripts arising from pGKL1 promoters tended to have longer and more uncapped 5' poly(A) leaders than pGKL2 transcripts ( Fig. 3C ; Table S1A ). Additionally, the 5' cap is more frequently present on the transcripts containing few or zero non-template adenosine nucleotides at their 5' ends (Table S1A ). The 5' ends of plasmid mRNAs resemble the organization of intermediate and late vaccinia virus mRNAs (75, 76) , late cowpox virus mRNAs (77) and even some plant mRNAs (78) that also contain non-templated poly(A)
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