Selected article for: "PBS control and viral infection"
Author: Smita Gopinath; Myoungjoo V. Kim; Tasfia Rakib; Patrick W. Wong; Michael van Zandt; Natasha A. Barry; Tsuneyasu Kaisho; Andrew L. Goodman; Akiko Iwasaki
Title: Microbiota-independent antiviral protection conferred by aminoglycoside antibiotics
  • Document date: 2018_1_16
    • ID: dzorkks5_15
    Snippet: To determine the link between ISG expression and antiviral protection, we compared the 158 ability of ISG-inducing and non-ISG inducing aminoglycosides to protect mice against 159 HSV-2 infection. We selected two ISG-inducing aminoglycosides (kasugamycin, sisomicin) 160 as well as the two non-ISG inducing aminoglycosides (amikacin, streptomycin). Mice pre-161 treated with non-ISG inducers were not protected against HSV-2 infection, with vaginal 1.....
    Document: To determine the link between ISG expression and antiviral protection, we compared the 158 ability of ISG-inducing and non-ISG inducing aminoglycosides to protect mice against 159 HSV-2 infection. We selected two ISG-inducing aminoglycosides (kasugamycin, sisomicin) 160 as well as the two non-ISG inducing aminoglycosides (amikacin, streptomycin). Mice pre-161 treated with non-ISG inducers were not protected against HSV-2 infection, with vaginal 162 viral titers and disease scores equivalent to those of PBS-treated control mice (Fig. 2e,f) . 163

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