Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients With Hypertension

Guang Yang; Zihu Tan; Ling Zhou; Min Yang; Lang Peng; Jinjin Liu; Jingling Cai; Ru Yang; Junyan Han; Yafei Huang; Shaobin He

The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.03. 31.20038935 doi: medRxiv preprint signs, laboratory findings, and treatment measures (ie, antiviral therapy, corticosteroid therapy) were extracted from electronic medical records and were recorded with standardized data collection forms. The data were reviewed by a trained team of physicians. Assessment of disease status followed the guideline of SARS-CoV-2 (The Fifth Trial Version of the Chinese National Health Commission): mild type, with slight clinical symptoms but no imaging presentations of pneumonia; common type, with fever, respiratory tract and other symptoms, imaging findings of pneumonia; severe type, with any of the following conditions: respiratory distress, respiratory frequency ≥30 times/minutes, finger oxygen saturation at rest ≤93%, or oxygenation index [PaO 2 / FiO 2 ]≤300 mmHg (1 mmHg=0.133 kPa); critical type, with any of the following conditions: respiratory failure requires mechanical ventilation, shock, combined with other organ failure requires intensive care unit care and treatment. 21 Laboratory parameters, including complete blood count, C-reactive protein (CRP), arterial blood gas analysis, myocardial injury markers, coagulation profile, serum biochemical tests (including renal and liver function, lactate dehydrogenase), procalcitonin (PCT), b-type natriuretic peptide (BNP), were measured according to the manufacturer's instructions.