Selected article for: "cationic polymer and immune response"
Author: Randall Toy; Pallab Pradhan; Vijayeetha Ramesh; Nelson C. Di Paolo; Blake Lash; Jiaying Liu; Emmeline L. Blanchard; Philip J. Santangelo; Dmitry M. Shayakhmetov; Krishnendu Roy
Title: Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways
  • Document date: 2019_5_24
    • ID: cbit5xci_4
    Snippet: These observations provide valuable insights on the in vivo immune response to cationic nanoparticles for nucleic acid delivery. They also established a detailed roadmap to better understand the origins of in vivo systemic toxicity of nanoparticles. The insights generated could allow rational design of improved cationic polymer formulations that can achieve optimal balance between toxicity and efficacy in vivo -thereby enabling their clinical tra.....
    Document: These observations provide valuable insights on the in vivo immune response to cationic nanoparticles for nucleic acid delivery. They also established a detailed roadmap to better understand the origins of in vivo systemic toxicity of nanoparticles. The insights generated could allow rational design of improved cationic polymer formulations that can achieve optimal balance between toxicity and efficacy in vivo -thereby enabling their clinical translation.

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