Selected article for: "airway inflammation and infection model"
Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation
  • Document date: 2019_7_22
    • ID: gg2ctmn7_16
    Snippet: Having characterised the expression of mucins during exacerbation, and noting that MUC5AC induction occurs at day 3, a time-point that precedes peak airway inflammation, which occurs between days 9 and 15 post-infection 1,15 , we next sought to assess relationships between MUC5AC responses and inflammatory responses to infection in our human experimental challenge model. We observed highly significant positive correlations between sputum MUC5AC a.....
    Document: Having characterised the expression of mucins during exacerbation, and noting that MUC5AC induction occurs at day 3, a time-point that precedes peak airway inflammation, which occurs between days 9 and 15 post-infection 1,15 , we next sought to assess relationships between MUC5AC responses and inflammatory responses to infection in our human experimental challenge model. We observed highly significant positive correlations between sputum MUC5AC and cellular airway inflammation (total cell counts and neutrophil counts, Fig.2d ) and between MUC5AC and concentrations of soluble mediators of inflammation including CXCL8/IL-8, CXCL10/IP-10, IL-1b, GM-CSF IL-6 and TNF (Fig.2d) .

    Search related documents:
    Co phrase search for related documents
    • airway inflammation and challenge model: 1, 2, 3
    • airway inflammation and inflammatory response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • airway inflammation and mucin expression: 1
    • airway inflammation and neutrophil count: 1
    • airway inflammation and positive correlation: 1, 2
    • airway inflammation and post infection: 1, 2, 3, 4, 5
    • airway inflammation and total cell count: 1, 2, 3, 4
    • cell count and inflammatory response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cell count and neutrophil count: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cell count and neutrophil count total cell count: 1, 2, 3, 4, 5, 6
    • cell count and positive correlation: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • cell count and post infection: 1, 2, 3, 4, 5, 6, 7
    • cell count and total cell count: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • challenge model and experimental challenge model: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • challenge model and human experimental challenge model: 1, 2, 3
    • challenge model and inflammatory response: 1, 2, 3
    • challenge model and mucin expression: 1
    • challenge model and post infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • experimental challenge model and post infection: 1