Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation Document date: 2019_7_22
ID: gg2ctmn7_16
Snippet: Having characterised the expression of mucins during exacerbation, and noting that MUC5AC induction occurs at day 3, a time-point that precedes peak airway inflammation, which occurs between days 9 and 15 post-infection 1,15 , we next sought to assess relationships between MUC5AC responses and inflammatory responses to infection in our human experimental challenge model. We observed highly significant positive correlations between sputum MUC5AC a.....
Document: Having characterised the expression of mucins during exacerbation, and noting that MUC5AC induction occurs at day 3, a time-point that precedes peak airway inflammation, which occurs between days 9 and 15 post-infection 1,15 , we next sought to assess relationships between MUC5AC responses and inflammatory responses to infection in our human experimental challenge model. We observed highly significant positive correlations between sputum MUC5AC and cellular airway inflammation (total cell counts and neutrophil counts, Fig.2d ) and between MUC5AC and concentrations of soluble mediators of inflammation including CXCL8/IL-8, CXCL10/IP-10, IL-1b, GM-CSF IL-6 and TNF (Fig.2d) .
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