Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation Document date: 2019_7_22
ID: gg2ctmn7_30
Snippet: Conversely, administration of MUC5B protein or a control polymer solution of agarose/dextran at the same concentration (0.5mg/mL) had no effect on inflammation, either alone or when administered in combination with RV infection in mice. (Supplementary Fig 5) Consistent with our hypothesis that MUC5AC drives neutrophil elastase-mediated cleavage of AMPs and subsequently increases bacterial loads, we also observed that exogenous MUC5AC increased .....
Document: Conversely, administration of MUC5B protein or a control polymer solution of agarose/dextran at the same concentration (0.5mg/mL) had no effect on inflammation, either alone or when administered in combination with RV infection in mice. (Supplementary Fig 5) Consistent with our hypothesis that MUC5AC drives neutrophil elastase-mediated cleavage of AMPs and subsequently increases bacterial loads, we also observed that exogenous MUC5AC increased RV-induction of neutrophil elastase (Fig.4e) , suppressed RV-induction of SLPI and augmented lung bacterial loads during virus infection (Fig.4f) . Similar to what author/funder. All rights reserved. No reuse allowed without permission.
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