Selected article for: "copd exacerbation and exacerbation severity"
Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation
  • Document date: 2019_7_22
    • ID: gg2ctmn7_57
    Snippet: In conclusion, we show that MUC5AC is the major induced mucin during virus infection in COPD and that virus-induced MUC5AC plays a central role in driving airway inflammation and exacerbation severity in COPD. Future development or repurposing of therapies that specifically target this component of mucus could lead to improved clinical outcomes. author/funder. All rights reserved. No reuse allowed without permission......
    Document: In conclusion, we show that MUC5AC is the major induced mucin during virus infection in COPD and that virus-induced MUC5AC plays a central role in driving airway inflammation and exacerbation severity in COPD. Future development or repurposing of therapies that specifically target this component of mucus could lead to improved clinical outcomes. author/funder. All rights reserved. No reuse allowed without permission.

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