Author: Jessica A. Plante; Kenneth S. Plante; Lisa E. Gralinski; Anne Beall; Martin T. Ferris; Daniel Bottomly; Richard Green; Shannon K. McWeeney; Mark T. Heise; Ralph S. Baric; Vineet D. Menachery
Title: Mucin 4 Protects Female Mice from Coronavirus Pathogenesis Document date: 2020_2_20
ID: 99sbhbuo_16
Snippet: Muc4 might impact viral tropism in a way not readily determined by the measurement of 104 infectious virus per lobe. Upon examining SARS-CoV antigen staining, however, no significant 105 differences in antigen distribution were noted between Muc4 -/and WT mice in either airway or 106 parenchymal staining ( Fig. 3B and 3C ). Together, the results indicated that the loss of Muc4 had 107 minimal impact on SARS-CoV viral load or distribution. female .....
Document: Muc4 might impact viral tropism in a way not readily determined by the measurement of 104 infectious virus per lobe. Upon examining SARS-CoV antigen staining, however, no significant 105 differences in antigen distribution were noted between Muc4 -/and WT mice in either airway or 106 parenchymal staining ( Fig. 3B and 3C ). Together, the results indicated that the loss of Muc4 had 107 minimal impact on SARS-CoV viral load or distribution. female Muc4 -/mice as compared to female WT mice. In contrast, male Muc4 -/mice induced 116 similar damage to male WT mice (Table S1) . 117
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