Author: Jessica A. Plante; Kenneth S. Plante; Lisa E. Gralinski; Anne Beall; Martin T. Ferris; Daniel Bottomly; Richard Green; Shannon K. McWeeney; Mark T. Heise; Ralph S. Baric; Vineet D. Menachery
Title: Mucin 4 Protects Female Mice from Coronavirus Pathogenesis Document date: 2020_2_20
ID: 99sbhbuo_8
Snippet: In earlier studies, incipient CC lines were used to identify four QTLs associated with 49 SARS-CoV phenotypes in female mice, one of which was mapped on the basis viral titer in the 50 lung at four DPI (Gralinski et al., 2015) . A subsequent study utilizing both male and female F2 51 mice derived from a highly susceptible and highly resistant CC mouse line identified five more 52 SARS-CoV-associated QTLs, three of which were mapped at least parti.....
Document: In earlier studies, incipient CC lines were used to identify four QTLs associated with 49 SARS-CoV phenotypes in female mice, one of which was mapped on the basis viral titer in the 50 lung at four DPI (Gralinski et al., 2015) . A subsequent study utilizing both male and female F2 51 mice derived from a highly susceptible and highly resistant CC mouse line identified five more 52 SARS-CoV-associated QTLs, three of which were mapped at least partially on the basis of viral 53 titer (Gralinski et al., 2017) . Located on chromosome 16 from nucleotides 31,583,769-54 36,719,997, the pre-CC QTL accounted for 22% of the variation in viral titer, which ranged from 55 over 10 8 PFU/lobe to below the limit of detection (10 2 PFU/lobe). The F2 QTLs, by comparison, 56
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