Selected article for: "prototype strain and viral nucleoprotein"
Author: John-Sebastian Eden; Rebecca Rockett; Ian Carter; Hossinur Rahman; Joep de Ligt; James Hadfield; Matthew Storey; Xiaoyun Ren; Rachel Tulloch; Kerri Basile; Jessica Wells; Roy Byun; Nicky Gilroy; Matthew V O’Sullivan; Vitali Sintchenko; Sharon C Chen; Susan Maddocks; Tania C Sorrell; Edward C Holmes; Dominic E Dwyer; Jen Kok
Title: An emergent clade of SARS-CoV-2 linked to returned travellers from Iran
  • Document date: 2020_3_17
    • ID: izkz1hz4_10
    Snippet: The Australian strains of SARS-CoV-2 were dispersed across the global SARS-CoV-2 phylogeny ( Figure 1A ). The first four cases of COVID-19 disease in NSW occurred between 24 and 26 January 2020, and these were closely related (with 1-2 SNPs difference) to the prototype strain MN908947/SARS-CoV-2/Wuhan-Hu-1, which is the dominant variant The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.1.....
    Document: The Australian strains of SARS-CoV-2 were dispersed across the global SARS-CoV-2 phylogeny ( Figure 1A ). The first four cases of COVID-19 disease in NSW occurred between 24 and 26 January 2020, and these were closely related (with 1-2 SNPs difference) to the prototype strain MN908947/SARS-CoV-2/Wuhan-Hu-1, which is the dominant variant The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.15.992818 doi: bioRxiv preprint 5 A search of partial sequences identified two SARS-CoV-2 sequences which originated in Iran (413553/IRN/Tehran15AW/2020-02-28 and 413554/IRN/Tehran9BE/2020-02-23) spanning a 363 nt region of the viral nucleoprotein (N). Although short in length, these two sequences covered one of the informative SNPs defining this clade -T28688C, and both Iranian strains matched the sequences from patients with travel histories to Iran and grouped by phylogenetic analysis (Supplementary Figures S1 & S2 ).

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