Selected article for: "cleavage site and furin cleavage site insertion"
Author: Aiping Wu; Peihua Niu; Lulan Wang; Hangyu Zhou; Xiang Zhao; Wenling Wang; Jingfeng Wang; Chengyang Ji; Xiao Ding; Xianyue Wang; Roujian Lu; Sarah Gold; Saba Aliyari; Shilei Zhang; Ellee Vikram; Angela Zou; Emily Lenh; Janet Chen; Fei Ye; Na Han; Yousong Peng; Haitao Guo; Guizhen Wu; Taijiao Jiang; Wenjie Tan; Genhong Cheng
Title: Mutations, Recombination and Insertion in the Evolution of 2019-nCoV
  • Document date: 2020_3_2
    • ID: jmrg4oeb_5
    Snippet: Although the fatality rate of 2019-nCoV is lower and the symptoms are milder than those of SARS, the transmissibility of 2019-nCoV appears to be higher 7 . The molecular mechanisms responsible for such rapid transmission and spread of the 2019-nCoV still remain elusive. Here, we have analyzed 120 2019-nCoV genome sequences including 11 novel strains isolated from patients to determine the viral evolution and divergence. 10 Our studies suggest tha.....
    Document: Although the fatality rate of 2019-nCoV is lower and the symptoms are milder than those of SARS, the transmissibility of 2019-nCoV appears to be higher 7 . The molecular mechanisms responsible for such rapid transmission and spread of the 2019-nCoV still remain elusive. Here, we have analyzed 120 2019-nCoV genome sequences including 11 novel strains isolated from patients to determine the viral evolution and divergence. 10 Our studies suggest that 2019-nCoV may increase its infectivity through the receptor binding domain recombination and a furin or TMPRSS2 cleavage site insertion. author/funder. All rights reserved. No reuse allowed without permission.

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