Author: Mehdi Baratchian; Jeff McManus; Mike Berk; Fumihiko Nakamura; Serpil Erzurum; Sanjay Mukhopadhyay; Judy Drazba; John Peterson; Ben Gaston; Nima Sharifi
Title: No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes Document date: 2020_4_21
ID: awb1stsr_2
Snippet: SARS-CoV-2 enters cells using two host cellular proteins: angiotensin converting enzyme-2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). The virus first employs ACE2 as a cell entry protein, followed by TMPRSS2-mediated proteolytic processing of the SARS-2 spike protein, further facilitating viral entry (Hoffmann et al., 2020) . Targeting the activity or expression of both factors by a plethora of approaches has been proposed as potential .....
Document: SARS-CoV-2 enters cells using two host cellular proteins: angiotensin converting enzyme-2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). The virus first employs ACE2 as a cell entry protein, followed by TMPRSS2-mediated proteolytic processing of the SARS-2 spike protein, further facilitating viral entry (Hoffmann et al., 2020) . Targeting the activity or expression of both factors by a plethora of approaches has been proposed as potential treatment (Hoffmann et al., 2020; Stopsack et al., 2020; Zhang et al., 2020) .
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