Author: Mehdi Baratchian; Jeff McManus; Mike Berk; Fumihiko Nakamura; Serpil Erzurum; Sanjay Mukhopadhyay; Judy Drazba; John Peterson; Ben Gaston; Nima Sharifi
Title: No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes Document date: 2020_4_21
ID: awb1stsr_5
Snippet: This raises the possibility that the physiological roles of androgens may, at least partially, account for the sex-specific clinical outcomes (Grasselli et al., 2020; Sharon Moalem, 2020) . Due to its androgen-regulated nature in the prostate and its essential role in SARS-Cov-2 etiology, TMPRSS2 expression has been postulated to follow a similar pattern of regulation in pulmonary cells by the potent androgens testosterone and dihydrotestosterone.....
Document: This raises the possibility that the physiological roles of androgens may, at least partially, account for the sex-specific clinical outcomes (Grasselli et al., 2020; Sharon Moalem, 2020) . Due to its androgen-regulated nature in the prostate and its essential role in SARS-Cov-2 etiology, TMPRSS2 expression has been postulated to follow a similar pattern of regulation in pulmonary cells by the potent androgens testosterone and dihydrotestosterone (Mikkonen et al., 2010) . If this link proves correct, it could pave the path to novel strategies, including re-purposing of FDA-approved potent androgen synthesis inhibitors or AR antagonists, such as enzalutamide (Enz) and apalutamide, for the treatment of COVID-19.
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