Selected article for: "new virus and RNA virus"
Author: Myra Hosmillo; Jia Lu; Michael R. McAllaster; James B. Eaglesham; Xinjie Wang; Edward Emmott; Patricia Domingues; Yasmin Chaudhry; Timothy J Fitzmaurice; Matthew K.H. Tung; Marc Panas; Gerald McInerney; Nicholas Locker; Craig B. Willen; Ian Goodfellow
Title: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation
  • Document date: 2019_3_8
    • ID: d0q5lhf4_36
    Snippet: In this study, we have used a combination of biochemical and genetic approaches to 380 identify host factors involved in the norovirus life cycle. Our combined approaches 381 resulted in the identification of the core stress granule component G3BP1 as a host 382 protein critical for the replication of both murine and human noroviruses in cell 383 culture. Furthermore, we determined that G3BP1 plays a key role in the processes of 384 norovirus VPg.....
    Document: In this study, we have used a combination of biochemical and genetic approaches to 380 identify host factors involved in the norovirus life cycle. Our combined approaches 381 resulted in the identification of the core stress granule component G3BP1 as a host 382 protein critical for the replication of both murine and human noroviruses in cell 383 culture. Furthermore, we determined that G3BP1 plays a key role in the processes of 384 norovirus VPg-dependent protein synthesis, uncovering a new function for G3BP1 in 385 facilitating RNA virus genome translation. 386

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