Author: Rui Xiong; Leike Zhang; Shiliang Li; Yuan Sun; Minyi Ding; Yong Wang; Yongliang Zhao; Yan Wu; Weijuan Shang; Xiaming Jiang; Jiwei Shan; Zihao Shen; Yi Tong; Liuxin Xu; Chen Yu; Yingle Liu; Gang Zou; Dimitri Lavillete; Zhenjiang Zhao; Rui Wang; Lili Zhu; Gengfu Xiao; Ke Lan; Honglin Li; Ke Xu
Title: Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2 Document date: 2020_3_12
ID: hq5um68k_8
Snippet: Additionally, the two inhibitors exhibited a clear trait of fast-associating (kon) and slowdissociating (koff) inhibition (Table S2) , providing themselves as ideal drug candidates with a high level of target occupancy. Moreover, S312 and S416 showed proper halflives (8.20 and 9.12 h, respectively) ( Table S3) , which are much shorter than that of Teriflunomide and Leflunomide, indicating that they may have less possibility to bring side effects .....
Document: Additionally, the two inhibitors exhibited a clear trait of fast-associating (kon) and slowdissociating (koff) inhibition (Table S2) , providing themselves as ideal drug candidates with a high level of target occupancy. Moreover, S312 and S416 showed proper halflives (8.20 and 9.12 h, respectively) ( Table S3) , which are much shorter than that of Teriflunomide and Leflunomide, indicating that they may have less possibility to bring side effects from drug accumulation in the body (Supplementary Data Fig. 1B and 1C ).
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