Author: Yongjun Tan; Theresa Schneider; Matthew Leong; L Aravind; Dapeng Zhang
Title: Novel Immunoglobulin Domain Proteins Provide Insights into Evolution and Pathogenesis Mechanisms of SARS-Related Coronaviruses Document date: 2020_3_7
ID: h5ire02h_9
Snippet: The Modeller9v1 program (Sali and Blundell, 1993) was utilized for homology modeling of structure of 115 SARS-CoV-2 ORF8 using the SARS-CoV ORF7 (1xak_A) (28) as a template. Since in these low sequence-116 identity cases, sequence alignment is the most important factor affecting the quality of the model 117 (Cozzetto and Tramontano, 2005) , alignments used in this study have been carefully built and cross-118 validated based on the information fr.....
Document: The Modeller9v1 program (Sali and Blundell, 1993) was utilized for homology modeling of structure of 115 SARS-CoV-2 ORF8 using the SARS-CoV ORF7 (1xak_A) (28) as a template. Since in these low sequence-116 identity cases, sequence alignment is the most important factor affecting the quality of the model 117 (Cozzetto and Tramontano, 2005) , alignments used in this study have been carefully built and cross-118 validated based on the information from HHpred and edited manually using the secondary structure 119 information. We generated five models and selected the one that had better model accuracy p-value 120
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