Author: Liwen Chen; Chaohua Deng; Xuhui Chen; Xian Zhang; Bo Chen; Huimin Yu; Yuanjun Qin; Ke Xiao; Hong Zhang; Xufang Sun
Title: Ocular manifestations and clinical characteristics of 534 cases of COVID-19 in China: A cross-sectional study Document date: 2020_3_16
ID: 5zrywg58_1
Snippet: The ongoing outbreak of the novel coronavirus disease (COVID-19) has been declared by WHO as a global public health emergency. COVID-19 was first reported in Wuhan, China, in December, 2019, followed by an outbreak across Hubei Province, other parts of China, and now all over the world, particularly in South Korea, Iran, Italy, and Japan. A study in the New England Journal of Medicine by Zhong Nanshan and colleagues 1 reported nine cases with con.....
Document: The ongoing outbreak of the novel coronavirus disease (COVID-19) has been declared by WHO as a global public health emergency. COVID-19 was first reported in Wuhan, China, in December, 2019, followed by an outbreak across Hubei Province, other parts of China, and now all over the world, particularly in South Korea, Iran, Italy, and Japan. A study in the New England Journal of Medicine by Zhong Nanshan and colleagues 1 reported nine cases with conjunctival congestion among the 1,099 cases enrolled. However, other ocular manifestations of COVID-19 are unknown, such as increased conjunctival secretion, epiphora, and diminution of vision. Several infected cases 2, 3 presented firstly with conjunctivitis before the onset of pneumonia, implying that the ocular route might be the potential transmission route of SARS-CoV-2 virus under certain conditions. A recent study revealed that SARS-CoV-2 also uses the cell entry receptor, angiotensin converting enzyme 2 (ACE2), 4, 5 similar to SARS-CoV. Moreover, the expression and activity of ACE2 can be detected in the ocular surface, including the cornea and conjunctiva, 6 which provides transocular entry potential for SARS-CoV-2.
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