Author: Darko Bosnakovski; Erik A. Toso; Olivia O. Recht; Anja Cucak; Abhinav K Jain; Michelle C. Barton; Michael Kyba
Title: p53 is not necessary for DUX4 pathology Document date: 2017_3_19
ID: jopeo9gs_17
Snippet: The previous study implicating p53 in DUX4 toxicity made use of a very different experimental system with vastly higher levels of DUX4 expression: recombinant adeno-associated virus vector-mediated production. The levels of DUX4 expression achieved in a cell infected with multiple copies of DUX4 driven from the CMV promoter are much higher than those in which DUX4 is expressed from its endogenous promoter from a single (terminal) D4Z4 repeat in A.....
Document: The previous study implicating p53 in DUX4 toxicity made use of a very different experimental system with vastly higher levels of DUX4 expression: recombinant adeno-associated virus vector-mediated production. The levels of DUX4 expression achieved in a cell infected with multiple copies of DUX4 driven from the CMV promoter are much higher than those in which DUX4 is expressed from its endogenous promoter from a single (terminal) D4Z4 repeat in All rights reserved. No reuse allowed without permission.
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