Author: Tao Zhang; Qunfu Wu; Zhigang Zhang
Title: Pangolin homology associated with 2019-nCoV Document date: 2020_2_20
ID: ao7bkcv5_1_1
Snippet: Accession MN908947) and RaTG13. The 7 Pangolin-Cov genome consists of six major open reading frames (ORFs) common to 8 coronaviruses and other four accessory genes ( Figure 1C and Table S2 ). Further analysis 9 indicates that Pangolin-Cov genes covered 2019-nCoV genes with coverage ranging from 10 45.8% to 100% (average coverage 76.9%). Pangolin-Cov genes shared high average 11 nucleotide and amino identity with both 2019-nCoV (MN908947) (93.2% n.....
Document: Accession MN908947) and RaTG13. The 7 Pangolin-Cov genome consists of six major open reading frames (ORFs) common to 8 coronaviruses and other four accessory genes ( Figure 1C and Table S2 ). Further analysis 9 indicates that Pangolin-Cov genes covered 2019-nCoV genes with coverage ranging from 10 45.8% to 100% (average coverage 76.9%). Pangolin-Cov genes shared high average 11 nucleotide and amino identity with both 2019-nCoV (MN908947) (93.2% nt/ 94.1% aa) 12 and RaTG13 (92.8% nt/93.5% aa) ( Figure 1C and Table S2) . Surprisingly, some of 13 Pangolin-Cov genes showed higher aa sequence identity to 2019-nCoV than RaTG13, 14 including orf1b (73.4/72.8), S-protein (97.5/95.4), orf7a (96.9/93.6), and orf10 (97.3/94.6).
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