Author: Hangping Yao; Xiangyun Lu; Qiong Chen; Kaijin Xu; Yu Chen; Linfang Cheng; Fumin Liu; Zhigang Wu; Haibo Wu; Changzhong Jin; Min Zheng; Nanping Wu; Chao Jiang; Lanjuan Li
Title: Patient-derived mutations impact pathogenicity of SARS-CoV-2 Document date: 2020_4_19
ID: 3eu9umx5_14
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.20060160 doi: medRxiv preprint 16 sequences and Taijima's D is -2.8874 with a nucleotide diversity (Ï€) of 0.000641 (p < 229 0.05 according to simulations performed in (Tajima, 1989) , indicating that the 230 SARS-CoV-2 genome has an excess of low-frequency alleles due to recent population 231 expansions, consistent with the repeated b.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.14.20060160 doi: medRxiv preprint 16 sequences and Taijima's D is -2.8874 with a nucleotide diversity (Ï€) of 0.000641 (p < 229 0.05 according to simulations performed in (Tajima, 1989) , indicating that the 230 SARS-CoV-2 genome has an excess of low-frequency alleles due to recent population 231 expansions, consistent with the repeated bottlenecking events during viral infections. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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