Author: Lubna A Al-Ansary; Ghada A Bawazeer; Elaine Beller; Justin Clark; John Conly; Chris Del Mar; Elizabeth Dooley; Eliana Ferroni; Paul Glasziou; Tammy Hoffman; Tom Jefferson; Sarah Thorning; Mieke van Driel; Mark Jones
Title: Physical interventions to interrupt or reduce the spread of respiratory viruses. Part 2 - Hand hygiene and other hygiene measures: systematic review and meta-analysis. Document date: 2020_4_20
ID: nt3jfein_12
Snippet: Pooling of eight trials [14] [15] [16] [17] [18] [19] 21] for the broad outcome of acute respiratory illness (ARI) showed a 16% relative reduction in the numbers of participants with ARI in the hand hygiene group (risk ratio (RR) 0.84, 95% CI 0.82 to 0.86) ( Figure 2 ). However, when considering the more strictly-defined outcomes of influenza-like illness (ILI) and laboratory-confirmed influenza (influenza) [15, 16, 20, [22] [23] [24] [25] [26] [.....
Document: Pooling of eight trials [14] [15] [16] [17] [18] [19] 21] for the broad outcome of acute respiratory illness (ARI) showed a 16% relative reduction in the numbers of participants with ARI in the hand hygiene group (risk ratio (RR) 0.84, 95% CI 0.82 to 0.86) ( Figure 2 ). However, when considering the more strictly-defined outcomes of influenza-like illness (ILI) and laboratory-confirmed influenza (influenza) [15, 16, 20, [22] [23] [24] [25] [26] [27] [28] , the results were heterogeneous and not as strongly in favour of hand hygiene (RR 0.98, 95% CI 0.85 to 1.14 for ILI; RR 0.91, 95% CI 0.61 to 1.34 for influenza). Three trials quantified absenteeism from school or work [17, 23, 30] and demonstrated a 36% relative reduction in the absentee numbers in the hand hygiene group (RR 0.64, 95% CI 0.58 to 0.71). All 15 trials could be pooled for analysis of the composite outcome 'ARI or ILI or influenza', each study contributing the most comprehensive outcome reported only once. This showed a statistically significant 10% relative reduction of participants with a respiratory illness in favour of hand hygiene (95% CI 0.84 to 0.96) but with high heterogeneity (Figure 2 ).
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