Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response Document date: 2020_4_14
ID: d7stppv5_41
Snippet: Second, effective dosing after symptom development predicts rapid subsequent elimination of infected. Most current clinical trials are focused primarily on hospitalized patients whereas our results and those from other COVID models suggest that treatment in the days immediately following symptom onset will decrease the duration of detectable viral shedding (24, 25) . Our model also predicts that early treatment will limit the extent of the cytoly.....
Document: Second, effective dosing after symptom development predicts rapid subsequent elimination of infected. Most current clinical trials are focused primarily on hospitalized patients whereas our results and those from other COVID models suggest that treatment in the days immediately following symptom onset will decrease the duration of detectable viral shedding (24, 25) . Our model also predicts that early treatment will limit the extent of the cytolytic immune response required to clear infection. If either of these outcomes are correlates of progression to severe disease and transmission risk, then as with HIV (26), influenza (27) , and Ebola (28), early test and treat is a vital, currently overlooked strategy.
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