Selected article for: "active nucleoside PBMCs triphosphate form and PBMCs triphosphate form"
Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response
  • Document date: 2020_4_14
    • ID: d7stppv5_73
    Snippet: To reproduce the PK data of RDV, we employed a simple two compartment model where the first compartment represents the amount of RDV in plasma ( 9 , volume 9 ) and the second compartment denotes the amount of its active nucleoside triphosphate form in PBMCs ( : , volume : ). Here, we assume that RDV gets metabolized to its active nucleoside triphosphate form at rate ;: whereas RDV and its active nucleoside triphosphate form are eliminated from th.....
    Document: To reproduce the PK data of RDV, we employed a simple two compartment model where the first compartment represents the amount of RDV in plasma ( 9 , volume 9 ) and the second compartment denotes the amount of its active nucleoside triphosphate form in PBMCs ( : , volume : ). Here, we assume that RDV gets metabolized to its active nucleoside triphosphate form at rate ;: whereas RDV and its active nucleoside triphosphate form are eliminated from their respective compartments at rates < and : , respectively. The model is given by, 9 = − ;: 9 − < 9 : = ;: 9 − : :

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