Author: Yujun Li; Haimin Wang; Xiaojuan Tang; Danting Ma; Chengzhi Du; Yifei Wang; Hong Pan; Qing Zou; Jie Zheng; Liangde Xu; Michael Farzan; Guocai Zhong
Title: Potential host range of multiple SARS-like coronaviruses and an improved ACE2-Fc variant that is potent against both SARS-CoV-2 and SARS-CoV-1 Document date: 2020_4_11
ID: dblrxlt1_6
Snippet: A VSV-G-pseudotyped reporter retrovirus whose entry is independent of ACE2 was used as a control Recombinant RBD and soluble ACE2 proteins have been shown to potently block SARS-CoV-1 89 entry 20,21 . To investigate whether similar approaches could also be applied to SARS-CoV-2, we first 90 produced IgG Fc fusion proteins of RBD (RBD-Fc) and soluble ACE2 (ACE2-Fc) variants (Fig. 4a) . 91 Specifically, the RBD variants include wildtype RBDs of SAR.....
Document: A VSV-G-pseudotyped reporter retrovirus whose entry is independent of ACE2 was used as a control Recombinant RBD and soluble ACE2 proteins have been shown to potently block SARS-CoV-1 89 entry 20,21 . To investigate whether similar approaches could also be applied to SARS-CoV-2, we first 90 produced IgG Fc fusion proteins of RBD (RBD-Fc) and soluble ACE2 (ACE2-Fc) variants (Fig. 4a) . 91 Specifically, the RBD variants include wildtype RBDs of SARS-CoV-1, Pangolin-CoV, and SARS-
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