Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19

Diogo de Moraes; Brunno Vivone Buquete Paiva; Sarah Santiloni Cury; João Pessoa Araújo Junior; Marcelo Alves da Silva Mori; Robson Francisco Carvalho

All data is available in the manuscript. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.07.030767 doi: bioRxiv preprint human samples in a t-distributed Stochastic Neighbor Embedding (tSNE) plot, as described previously 20 . Grey dots represent single-cells from pulmonary fibrosis samples that were not included in the present analysis. Single-cell gene expression of TRIB3 (B), HAPLN2 (C), and ACE2 (D) in different cell populations of the lung. The images were generated using the dataset 20 , available at nupulmonary.org/resources/. The range represents the minimum and maximum expression. Figure S3 . Heatmap with the mean expression of DEGs on female samples (n=129), normalized by the Trimmed Mean of M-values (TMM) and Z-scored by row. Fewer genes clustered on gradients compared with males (Figure 1) , which could mean a more substantial noise on the data due to decreased sample size or female hormonal cycle.