Author: Diogo de Moraes; Brunno Vivone Buquete Paiva; Sarah Santiloni Cury; João Pessoa Araújo Junior; Marcelo Alves da Silva Mori; Robson Francisco Carvalho
Title: Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19 Document date: 2020_4_9
ID: hbystii6_4
Snippet: was predicted to interact with virus proteins spike glycoprotein and E2 glycoprotein precursors, while TRIB3 with nucleocapsid protein and RNA-dependent RNA polymerase ( Figure 1b ; Table S3 ). Importantly, the SARS-CoV-2 nucleocapsid protein has a sequence identity of 89.6% compared to SARS-CoV 9 . The expression of TRIB3 also decreased in the lung, specifically in males with ≥ 40 years (Figure 1c) , in a cohort with additional samples (GTEx.....
Document: was predicted to interact with virus proteins spike glycoprotein and E2 glycoprotein precursors, while TRIB3 with nucleocapsid protein and RNA-dependent RNA polymerase ( Figure 1b ; Table S3 ). Importantly, the SARS-CoV-2 nucleocapsid protein has a sequence identity of 89.6% compared to SARS-CoV 9 . The expression of TRIB3 also decreased in the lung, specifically in males with ≥ 40 years (Figure 1c) , in a cohort with additional samples (GTEx, release V8).
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