Selected article for: "primer probe and probe primer"
Author: Chantal B.F. Vogels; Anderson F. Brito; Anne Louise Wyllie; Joseph R Fauver; Isabel M. Ott; Chaney C. Kalinich; Mary E. Petrone; Marie-Louise Landry; Ellen F. Foxman; Nathan D. Grubaugh
Title: Analytical sensitivity and efficiency comparisons of SARS-COV-2 qRT-PCR assays
  • Document date: 2020_4_1
    • ID: 6mdimxnk_27
    Snippet: The exact cause of the background cross-reactivity when testing clinical samples from pre-COVID-19 respiratory disease patients using the China CDC and US CDC primer-probe sets is unknown. One possibility is that these primers and probes can slightly amplify other seasonal coronaviruses. We did not detect cross-reactivity when using the Charité and HKU sets, and indeed, the assay developers reported that the primers and probes did not detect oth.....
    Document: The exact cause of the background cross-reactivity when testing clinical samples from pre-COVID-19 respiratory disease patients using the China CDC and US CDC primer-probe sets is unknown. One possibility is that these primers and probes can slightly amplify other seasonal coronaviruses. We did not detect cross-reactivity when using the Charité and HKU sets, and indeed, the assay developers reported that the primers and probes did not detect other circulating coronaviruses and respiratory viruses 4, 5 . Cross-reactivity with other viruses would severely limit the utility of any assay and requires further investigation.

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