Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients With Hypertension

Guang Yang; Zihu Tan; Ling Zhou; Min Yang; Lang Peng; Jinjin Liu; Jingling Cai; Ru Yang; Junyan Han; Yafei Huang; Shaobin He

Nevertheless, as far as we know, this is the largest retrospective cohort study designed to examine the usage of ARBs/ACEIs and its effect on COVID-19 patients with preexisting hypertension. Second, the severity and disease course were not identical among these patients, which resulted in the difficulty in collecting laboratory indicators at the same time point, we therefore selected the most extreme values beyond the normal range of laboratory indicators that could reflect the severity of condition for comparison. However, this strategy might still cause biases in presenting laboratory indicators. Third, the expression of ACE2 and other inflammatory factors were not determined in this study due to the sample availability and limited technical resources in our hospital, this limitation prevented us from further exploring All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.