Selected article for: "cc NC ND International license and disease severity"
Author: Xiaomin Luo; Wei Zhou; Xiaojie Yan; Tangxi Guo; Benchao Wang; Hongxia Xia; Lu Ye; Jun Xiong; Zongping Jiang; Yu Liu; Bicheng Zhang; Weize Yang
Title: Prognostic value of C-reactive protein in patients with COVID-19
  • Document date: 2020_3_23
    • ID: m76ic66s_24
    Snippet: The pathological mechanism of COVID-19 has not been fully uncovered. In this study, the median age of non-survivors was 71 (64-80) years, significantly higher than 57 (40-69) years in survivors. Further, age was an independent predictor of adverse outcome and discriminator of severe/critical illness, which suggested that old people are more vulnerable to SARS-CoV-2 and more likely to develop severe/critical disease. 5, 6, 8 Elevated neutrophil co.....
    Document: The pathological mechanism of COVID-19 has not been fully uncovered. In this study, the median age of non-survivors was 71 (64-80) years, significantly higher than 57 (40-69) years in survivors. Further, age was an independent predictor of adverse outcome and discriminator of severe/critical illness, which suggested that old people are more vulnerable to SARS-CoV-2 and more likely to develop severe/critical disease. 5, 6, 8 Elevated neutrophil count was observed in patients with severe illness compared to those with non-severe illness. 7 In this study, admission neutrophil count was a moderate predictor of clinical outcome and disease severity. These results implied that factors contributing to raised neutrophil count, such as secondary infection, excessive inflammatory stress or glucocorticoids use, might exacerbate disease progression in patients with COVID-19. Reduction in peripheral lymphocyte count was commonly observed in patients with COVID-19, which was considered a possible critical factor associated with disease severity and mortality. 12, 13 Reduced CD4 and CD8 T cell count accompanied by their over-activation might contribute to the impaired immunity and disease progression in patients with COVID-19. 12 In this study, significant discrepancy was observed in lymphocyte count between patients with different outcome or disease severity. NLR, an inflammatory index defined by neutrophil count divided by lymphocyte count, was found to be associated with sepsis . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

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